NAD+, glutathione, sermorelin, peptides, hormone therapy around menopause, and the science of aging, with a clear line between what human studies show and what is still unknown.
Other topics: Weight Loss · Sexual Health · Hair & Skin
13 articles
In published studies, the most commonly reported sermorelin side effects were brief facial flushing and pain at the injection site. Long-term safety data in adults are limited, and related drugs carry warnings about blood sugar, fluid retention and active cancer.
Read articleSermorelin is a lab-made copy of the first 29 amino acids of growth hormone-releasing hormone. It signals the pituitary to release its own growth hormone rather than supplying the hormone directly. The US brand was discontinued, and compounded sermorelin is not FDA-approved.
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Peptides are short chains of amino acids. A few are FDA-approved drugs, but many prescribed peptides are compounded, which means they are not FDA-approved. FDA rules decide which peptide ingredients pharmacies may use, and those rules shifted between 2023 and 2026.
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Off-label prescribing means using an FDA-approved drug for a condition, dose, form or population that is not in its label. It is legal and common, but the FDA has not reviewed that use, and the supporting evidence ranges from strong to thin.
Read articleNAD+ can be given by IV infusion, injection under the skin or nasal spray, but human data on these routes are small, short and mostly limited to blood levels and tolerability. No route has been shown to improve health outcomes in controlled trials.
Read articleInflammaging is the chronic, low-grade inflammation that tends to build up with age. It is linked to heart disease, diabetes, frailty and other conditions of later life, and one major trial suggests lowering inflammation can reduce repeat heart events in some people.
Read articleScientists group the biology of aging into 12 hallmarks, such as DNA damage, shortening telomeres, failing mitochondria and chronic inflammation. They are interconnected, and most of the evidence that targeting them slows aging comes from animal studies, not people.
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Glutathione is an antioxidant your cells make from three amino acids. Human trials of supplemental glutathione are small and mixed, and injected glutathione has not been shown to benefit healthy adults. Compounded glutathione is not FDA-approved.
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Estradiol and progesterone are available as FDA-approved products that are chemically identical to the body's hormones. Biest is a compounded cream that mixes estriol with estradiol; it is not FDA-approved, and expert bodies advise using it only when an approved product will not work.
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Blue Zones are regions reported to have unusually many people living to 100. The research suggests habits such as activity, plant-rich diets and social connection matter, but it is observational, and some age records have been questioned. It is inspiration, not proof.
Read articleChronological age is the time since you were born. Biological age is an estimate, usually from blood chemistry or DNA methylation, of how your body is aging. Aging clocks predict health risks across groups, but single readings can be noisy and are not diagnoses.
Read articleWhat changes during the menopausal transition, which symptoms hormone therapy treats, how FDA-approved products differ from compounded ones, and what the 2025 label changes mean.
Read articleNAD+ is a coenzyme found in every cell, and interest in boosting it has surged. A grounded look at its biology, the human studies that exist, and the gap between laboratory findings and marketing claims.
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